Which medication is metabolized by the enzyme CYP2D6?

Which medication is metabolized by the enzyme CYP2D6?

• A. Ibuprofen
• B. Codeine
• C. Acetaminophen
• D. Aspirin

Answer: (B)

Codeine is metabolized by the enzyme CYP2D6, primarily in the liver. This enzyme plays a crucial role in converting codeine into its active form, morphine, which is responsible for its analgesic effects. The metabolic pathway that involves CYP2D6 is significant because it affects how different individuals respond to codeine. Variability in CYP2D6 enzyme activity due to genetic differences can lead to variations in pain relief or an increased risk of side effects in some patients. The other medications mentioned do not rely on CYP2D6 for metabolism. Ibuprofen and aspirin are primarily metabolized by other enzymes in the liver, while acetaminophen has its own metabolic pathways that do not involve CYP2D6. Understanding the specific metabolic processes of these drugs helps in anticipating possible drug interactions and the effectiveness of the medication in different patients.

Codeine is metabolized by the enzyme CYP2D6, primarily in the liver. This enzyme plays a crucial role in converting codeine into its active form, morphine, which is responsible for its analgesic effects. The metabolic pathway that involves CYP2D6 is significant because it affects how different individuals respond to codeine. Variability in CYP2D6 enzyme activity due to genetic differences can lead to variations in pain relief or an increased risk of side effects in some patients.

The other medications mentioned do not rely on CYP2D6 for metabolism. Ibuprofen and aspirin are primarily metabolized by other enzymes in the liver, while acetaminophen has its own metabolic pathways that do not involve CYP2D6. Understanding the specific metabolic processes of these drugs helps in anticipating possible drug interactions and the effectiveness of the medication in different patients.