What protein is primarily affected in Pemphigus Vulgaris?

What protein is primarily affected in Pemphigus Vulgaris?

• A. Desmoglein III
• B. Keratin
• C. Cadherin
• D. Collagen

Answer: (A)

In Pemphigus Vulgaris, the primary protein affected is desmoglein III. This condition is an autoimmune blistering disorder characterized by the presence of autoantibodies targeting desmogleins, which are vital proteins involved in the adhesion of keratinocytes in the epidermis. Desmogleins are part of the cadherin family of proteins, and specifically, desmoglein III plays a critical role in maintaining cell-to-cell adhesion in the oral mucosa and skin. The binding of autoantibodies to desmoglein III disrupts adhesion, leading to the loss of cohesion between keratinocytes, which subsequently results in the formation of blisters and erosions seen in Pemphigus Vulgaris. This highlights the importance of desmoglein III as a key player in the pathology of the disease, making it the correct answer to the question. Other proteins mentioned, such as keratin, cadherin, and collagen, do not have the same direct involvement in the etiology of Pemphigus Vulgaris. While keratin is an essential structural protein in the skin and cadherins represent a broader category of adhesion molecules, desmoglein III is the specific target affected in this autoimmune

In Pemphigus Vulgaris, the primary protein affected is desmoglein III. This condition is an autoimmune blistering disorder characterized by the presence of autoantibodies targeting desmogleins, which are vital proteins involved in the adhesion of keratinocytes in the epidermis. Desmogleins are part of the cadherin family of proteins, and specifically, desmoglein III plays a critical role in maintaining cell-to-cell adhesion in the oral mucosa and skin.

The binding of autoantibodies to desmoglein III disrupts adhesion, leading to the loss of cohesion between keratinocytes, which subsequently results in the formation of blisters and erosions seen in Pemphigus Vulgaris. This highlights the importance of desmoglein III as a key player in the pathology of the disease, making it the correct answer to the question.

Other proteins mentioned, such as keratin, cadherin, and collagen, do not have the same direct involvement in the etiology of Pemphigus Vulgaris. While keratin is an essential structural protein in the skin and cadherins represent a broader category of adhesion molecules, desmoglein III is the specific target affected in this autoimmune