What mode of inheritance is associated with Nevoid basal cell carcinoma?

What mode of inheritance is associated with Nevoid basal cell carcinoma?

• A. Autosomal recessive
• B. Autosomal dominant
• C. X-linked dominant
• D. Polygenic inheritance

Answer: (B)

Nevoid basal cell carcinoma syndrome, also known as Gorlin syndrome, is associated with autosomal dominant inheritance. This means that an individual only needs one copy of the mutated gene, which is located on chromosome 9, to manifest the syndrome. The mutation typically affects the PTCH1 gene, which is important for controlling cell growth and division. As a result, individuals with this syndrome have an increased risk of developing multiple basal cell carcinomas, along with other abnormalities such as jaw cysts and skeletal malformations. In autosomal dominant conditions, the syndrome can be passed from affected individuals to their offspring, resulting in a range of expression of the condition in subsequent generations. This mode of inheritance contrasts with autosomal recessive conditions, where two copies of the mutated gene are required for the disease to manifest, and X-linked conditions that typically involve mutations on the sex chromosomes. Polygenic inheritance involves multiple genes contributing to a trait and does not fit the inheritance pattern of Nevoid basal cell carcinoma syndrome. Thus, the classification as autosomal dominant accurately describes the familial transmission and manifestation of this condition.

Nevoid basal cell carcinoma syndrome, also known as Gorlin syndrome, is associated with autosomal dominant inheritance. This means that an individual only needs one copy of the mutated gene, which is located on chromosome 9, to manifest the syndrome. The mutation typically affects the PTCH1 gene, which is important for controlling cell growth and division. As a result, individuals with this syndrome have an increased risk of developing multiple basal cell carcinomas, along with other abnormalities such as jaw cysts and skeletal malformations.

In autosomal dominant conditions, the syndrome can be passed from affected individuals to their offspring, resulting in a range of expression of the condition in subsequent generations. This mode of inheritance contrasts with autosomal recessive conditions, where two copies of the mutated gene are required for the disease to manifest, and X-linked conditions that typically involve mutations on the sex chromosomes. Polygenic inheritance involves multiple genes contributing to a trait and does not fit the inheritance pattern of Nevoid basal cell carcinoma syndrome. Thus, the classification as autosomal dominant accurately describes the familial transmission and manifestation of this condition.